Evaluation of Oogenesis Aspects in Neonatal and Adult Mice after Toloaldoxime Treatment
نویسندگان
چکیده
OBJECTIVE Oximes are important materials in organic chemistry. Synparamethyl benzal- dehyde oxime (toloaldoxime) is structurally similar to other oximes, hence we have studied its effects on the neonatal and adult female Balb/c mice reproductive systems in order to provide a platform for future studies on the production of female contraceptive drugs. MATERIALS AND METHODS In experimental study, we studied the effects of toloaldoxime on ovary growth and gonadal hormones of neonatal and adult Balb/c mice. A regression model for prediction was presented. RESULTS The effects of toloaldoxime on neonatal mice were more than adult mice. The greatest effect was on the number of Graafian follicles (59.6% in adult mice and 31.83% in neonatal mice). The least effect was on ovary weight, and blood serum lev- els of follicle stimulating hormone (FSH) and luteinizing hormone (LH). CONCLUSION According to the data obtained, toloaldoxime can be considered an anti- pregnancy substance.
منابع مشابه
Effect of maternal anastrozole treatment on ovarian follicle development in neonatal mouse: A morphologic study
Introduction: The origin of neonatal oocyte development is unknown. However, estrogen plays an essential role during development of the female reproductive system. Anastrozole is used as both ovulation stimulating and an anticancer drug. The aim of this study was to evaluate the impact of Anastrozole on follicular development and differentiation in mice. Materials and methods: In the present s...
متن کاملFoeniculum vulgare (Fennel) Effects on Puberty Timing, Reproductive Function and Behaviour in Adult Female Mice Following Neonatal Exposure
Background & Objective: Fennel, as an edible plant, and due to its estrogenic compounds, has widely been used as a therapeutic agent for centuries. In this study, the effects of neonatal exposure to fennel alcoholic extract (FAE), on the onset of puberty, estrus cycle, ovaries, and lordosis were investigated. Materials & Methods: In this experimental study, 48 female BALB/c pups were divid...
متن کاملEffect of Camphor on Pituitary-Gonadal Hormonal Axis and Oogenesis in Adult Female Rats
Background & Objective: Camphor stimulates the nervous system and the circulatory system, reduces lactation, and prevents conception and embryo embedding. We investigated the effects of camphor on the pituitary-gonadal hormonal axis and concentration of steroidal hormones. Materials & Methods: The parameters investigated were concentrations of LH, FSH, estrogen, progesterone, and testosterone...
متن کاملComparison of Neonatal and Adult Mice-derived Sertoli Cells in Support of Expansion of Mouse Spermatogonial Stem Cells In vitro
متن کامل
Assessment of In Vitro-Derived Germ Cells Contribution in Oogenesis in Female Mice Ovaries
Introduction: Contrary to a common belief, most mammalian females lose the ability of Germ Cell (GC) renewal and oogenesis during fetal life. Although, it has been claimed that germ line stem cells preserve oogenesis in postnatal mouse ovaries, that postnatal oogenesis keeps producing functional and sufficient GCs in the case of infertility (caused by different reasons) is doubtful. On the othe...
متن کامل